ARE ALL COVID-19 VACCINES CREATED EQUAL?


Coronavirus instances are falling in lots of elements of the nation. Greater than 40 million People have been vaccinated. I’m 67 years of age and eligible for the coronavirus vaccine. On Thursday, February 4th I acquired my first Moderna vaccine shot. On March 2nd I’ll obtain my second dose.

For weeks now, COVID vaccinations have begun in the USA. Sadly, many individuals eligible for the vaccine are having hassle making appointments.

Solely two vaccines by Moderna and Pfizer have been FDA authorised for emergency use to stop coronavirus illness (COVID-19) brought on by SARS-CoV-2. On Thursday, February fifth Johnson & Johnson submitted an software to the Meals and Drug administration (FDA) for emergency authorization. Johnson & Johnson says they will start delivery early March as quickly as FDA approves it. The approval of a 3rd vaccine would speed up the vaccine rollout in the USA and decrease coronavirus instances, hospitalizations and deaths.

One benefit of the Johnson & Johnson COVID vaccine is that it’s given in a single dose, whereas the vaccines from Moderna and Pfizer are administered as two doses. One other good thing about Johnson & Johnson’s vaccine is that it may be saved beneath refrigeration, whereas the Moderna and Pfizer vaccines should be saved in a freezer at a lot colder temperatures.

The Johnson & Johnson vaccine is just 66% efficient primarily based on a global medical trial at stopping average and extreme COVID-19 illness. The Pfizer vaccine confirmed 95% efficacy in stopping symptomatic COVID infections after two doses, whereas the Moderna vaccine was 91.2% efficient after the second dose.

A fourth COVID-19 vaccine by Oxford-AstraZeneca is emergency-use authorised in European and different nations. It’s not but authorised in the USA due to the shortage of knowledge on the efficacy in older individuals. The AstraZeneca vaccine confirmed solely 62% efficacy after its two doses in medical trials. Most not too long ago, South Africa halted AstraZeneca COVID vaccines after a small medical trial discovered that the vaccine didn’t shield individuals from the brand new mutated variant and from delicate and average sickness, and confirmed it was solely 10% efficient. Just like the Johnson & Johnson vaccine, the AstraZeneca vaccine could be saved beneath regular refrigeration situations.

mRNA VERSUS DNA COVID VACCINES

The Moderna and Pfizer vaccines are mRNA vaccines. mRNA vaccines don’t change your DNA. They comprise messenger ribonucleic acid. Johnson & Johnson and AstraZeneca are DNA vaccines. “In contrast with DNA-based vaccines, mRNA doesn’t combine into the hosts’ genome, thus minimizing the genotoxicity situation.” (Adv Drug Deliv, February 2021.) In keeping with Bryn Boslett, MD, a famend infectious illness professional from the College of California, San Francisco, who acknowledged within the publication Affected person Care on January 27, 2021, “It’s principally a chunk of fabric that accommodates directions,” mentioned Dr. Boslett. “As soon as its injected, it taken up by your cells, nevertheless it by no means enters the cell nucleus the place your whole DNA exists inside your cells.”

The Affected person Care article says, “The mRNA accommodates directions in your cells to make spike proteins that match those discovered on the floor of the SARS-CoV-2 virus, which brought about COVID-19. When your cells current these spike proteins on their floor, your physique acknowledges them as international and develops an immune response, together with antibodies particular to the spike protein.” The mRNA is simply “a brief message,” mentioned Dr. Boslett. “After the spike protein will get made, your physique destroys the mRNA so it doesn’t stick round within the physique. It doesn’t combine with any genetic code. It doesn’t go into your DNA. I’m by no means nervous about there being any type of harm to an individual’s DNA from vaccines.”

Many high infectious illness specialists are involved with the brand new mutated variants within the UK, Brazil and South Africa that may make the vaccines much less efficient. These mutated variants are transmitted extra effectively however should not extra lethal. Moderna, Pfizer, Johnson & Johnson and AstraZeneca are engaged on booster photographs for the vaccines to ensure their current vaccines will work towards the brand new variants and forestall one other surge. We don’t know but if these booster photographs shall be wanted. The South African variant is most regarding! Within the Johnson & Johnson medical trial, their vaccine had a 57% efficacy price towards average to extreme illness.

4 OUT OF 10 AMERICANS DON’T PLAN ON GETTING VACCINATED

Pew Analysis Heart, a nonpartisan truth tank, has mentioned that just about 4 in 10 People say they don’t plan on getting vaccinated. Many People are reluctant and never interested by vaccination. Some view COVID-19 vaccines with suspicion, leading to anti-vaccine attitudes. Additionally, there’s anti-government anger, regardless that well being authorities together with the Facilities for Illness Management and Prevention (CDC) say COVID vaccinations are secure and that critical hostile results look like unusual. Primarily based on the science and medical trial information, there’s really little proof of great uncomfortable side effects in tens of millions who’ve already been vaccinated. Primarily based on well being division information, Black People and Latinos are much less prone to get vaccinated due to a mistrust of our well being care system, regardless that the coronavirus is extra lethal in Blacks and Latinos.

Just like the flu shot, COVID vaccines could trigger uncomfortable side effects in some individuals. Frail and sick individuals over 80 years of age could be on the highest danger. COVID vaccines could also be too dangerous for the very previous and terminally unwell. It has not too long ago been reported in The New York Instances on February 9, 2021, that some older sufferers are experiencing hostile uncomfortable side effects equivalent to a uncommon blood situation referred to as “immune thrombocytopenia – a scarcity of platelets, a blood element important for clotting.” The article additionally states, “It’s not identified whether or not this blood dysfunction is expounded to the COVID vaccines. Greater than 31 million individuals in the USA have acquired no less than one dose, and 36 related instances had been reported to the federal government’s Vaccine Opposed Occasion Reporting System, VAERS, by the tip of January. The instances concerned both the Pfizer-BioNTech or Moderna vaccine, the one two licensed to this point for emergency use in the USA.”

The CDC recommends anybody with a historical past of allergic reactions or anaphylaxis ought to seek the advice of their doctor earlier than taking the vaccine, after which be noticed half-hour after injection. Different recipients ought to solely be noticed for quarter-hour.

Some potential non-serious uncomfortable side effects of Moderna and Pfizer vaccines are fever, chills, complications, and fatigue. Additionally, injection website ache and swelling for a number of days. Research have proven stronger uncomfortable side effects after the second shot. Uncomfortable side effects imply the vaccine is working and your immune system is reacting.

Transferring ahead, public well being authorities should be as clear as potential with efficient methods to guarantee the general public that vaccines are secure and efficient, easing fears!

Many infectious illness specialists estimate that 70% to 85% of the inhabitants in the USA must be vaccinated to realize herd immunity and assist comprise the unfold of this contagious illness. Hopefully, this may be achieved earlier than the tip of 2021, so long as extra individuals get vaccinated and the mutated variants don’t set us again. Within the interim, as extra individuals get vaccinated, rising immunity will happen and make life extra livable and particularly when the climate will get hotter as we head into spring and summer season.

© Revealed by Superior Analysis Media, Inc. 2021

References:

1. Park KS, Solar X, Aikins ME, Moon JJ. Non-viral COVID-19 vaccine supply techniques. Adv Drug Deliv Rev 2021 Feb;169:137-151. doi: 10.1016/j.addr.2020.12.008. Epub 2020 Dec 17. PMID: 33340620; PMCID: PMC7744276.

2. Ura T, Yamashita A, Mizuki N, Okuda Okay, Shimada M. New vaccine manufacturing platforms utilized in growing SARS-CoV-2 vaccine candidates. Vaccine 2021;39(2):197-201. doi:10.1016/j.vaccine.2020.11.054

3. Karpiński TM, Ożarowski M, Seremak-Mrozikiewicz A, Wolski H, Wlodkowic D. The 2020 race in direction of SARS-CoV-2 particular vaccines. Theranostics 2021 Jan 1;11(4):1690-1702. doi: 10.7150/thno.53691. PMID: 33408775; PMCID: PMC7778607.

4. COVID-19 Vaccine Reality Vs. Fiction: An Knowledgeable Weighs in on Widespread Fears. Nina Bai. Affected person care, January 27, 2021. https://www.ucsf.edu/information/2021/01/419691/covid-19-vaccine-fact-vs-fiction-expert-weighs-common-fears

5. Guaranteeing the Security of Vaccines. Facilities for Illness Management & Prevention (CDC.) January 28,

2021 https://www.cdc.gov/coronavirus/2019-ncov/vaccines/security.html

6. Efficacy and Security of the mRNA-1273 SARS-CoV-2 Vaccine. Baden, Lindsey R., El Sahly, Hana M., Essink, Brandon et al. 2/04/2021. NEJM. doi: 10.1056/NEJMoa2035389

7. Sustaining Security with SARS-CoV-2 Vaccines. Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D. 12/30/2020. NEJM. DOI: 10.1056/NEJMra2035343

8. Security and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. Fernando P. Polack, MD, et al.  NEJM. 12/31/2020. https://www.nejm.org/doi/full/10.1056/NEJMoa2034577

9. Cohen, A.F., van Gerven, J., Burgos, J.G., de Boer, A., Foucher, R.A.M., Flore, H., Teitelbaum, Z., van Eden, W., Webb, A. and Cremers, S. (2020), COVID19 vaccines: the significance of transparency and truthprimarily based schooling. Br J Clin Pharmacol 86: 2107-2110. https://doi.org/10.1111/bcp.14581

10. Zhou P, Li Z, Xie L, An D, Fan Y, Wang X, Li Y, Liu X, Wu J, Li G, Li Q. Analysis progress and challenges to coronavirus vaccine improvement. J Med Virol. 2021 Feb;93(2):741-754. doi: 10.1002/jmv.26517. Epub 2020 Oct 7. PMID: 32936465.

11. A Few Covid Vaccine Recipients Developed a Uncommon Blood Dysfunction by Denise Grady. February 9, 2021. https://www.nytimes.com/2021/02/08/well being/immune-thrombocytopenia-covid-vaccine-blood.html





Supply hyperlink

Leave a Reply

Your email address will not be published. Required fields are marked *